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Please note, the following information is intended for information only. Please contact your hospital/clinician if you require clinical advice, or guidance on patient suitability, allergies etc. Further advice for clinicians,  available on request.

Colon Transit 3 x 2 - Marker Studies

Indication: Adult and paediatric patients with severe constipation but otherwise negative GI evaluations. Colon Transit is to be used only under the instructions of a physician.

Description
Six gelatin capsules, each containing 10 radiopaque polyurethane ring markers containing 40% barium sulphate USP. The capsules are numbered.  Each pair of 2 capsules have the same geometry of radiopaque markers. The marker shapes are as follows: day 1 - spheres, day 2 - small rods, day 3 - rings. All Six (6) capsules should be used per patient. Each capsule contains 10 radioopaque markers which do not undergo any changes in the gastrointestinal tract. Without any special preparation of the patient, it is possible to reconstruct the activity of the colon.

Procedure ATTENTION: It is essential that the following procedure is strictly followed. Since the examination requires a minimum of 6 days, avoid weeks containing holidays or other days which might interfere with the sequence. No laxatives should be used before or during the study.

Day 1 -  Patient takes the two capsules labelled 1 at breakfast time.  
Day 2 -  Patient takes the two capsules labelled 2 at breakfast time.
Day 3 -  Patient takes the two capsules labelled 3 at breakfast time.
Day 5 -  Patient returns to the hospital for an upper abdominal x-ray at the appointed time.

For patients with swallowing difficulties, capsule intolerant patients, or children over the age of 5, the capsules can be opened and the markers placed in a pudding, jello, jelly, yogurt or similar easy-to-swallow food for the patient to eat instead of swallowing a capsule.

Normal subjects retain more than 20% of markers within 12 hours and less than 80% after 120 hour. If desired more information can be gained by giving different types of marker on successive days, so that several transit studies providing intermediate values can be obtained from a single abdominal radiograph at 120 hours.